Aloe-emodin

Detailed Product Description

  Detailed Product Description

Synonym	Aloe-emodin
Molecular Formula	C15H10O5
Molecular Weight	270.23
CAS Number	481-72-1

Specification

Pharmacological Efficacy:
(A) Anti-tumor Activity:
Aloe-emodin on the inhibition of P388 leukemia cells, extended survival time. Its role is one of the mechanisms of cancer cells inhibited DNA, RNA and protein biosynthesis.
(B) Antibacterial Activity:
In the 1.5 ~ 25mg/ml concentration of aloe-emodin on staphylococcus, streptococcus, diphtheria bacillus, Bacillus subtilis, anthrax, paratyphoid bacillus, and so inhibit Shigella, Staphylococcus and Streptococcus in which the most sensitive, or effective concentration of bacteria 15-25ug/ml. Against Staphylococcus aureus 209P, E. coli, Shigella dysenteriae in vitro inhibitory concentration of 7.5mg / L, 600mg / L of its antibacterial activity are bacteriostatic rather than bactericidal. One of its mechanism of inhibition of mitochondrial respiratory chain electron transfer. Aloe-emodin on Staphylococcus aureus nucleic acid and protein synthesis inhibition strong. Aloe-emodin common clinical anaerobic bacteria have a strong inhibitory effect, in which the vulnerability of common bacteria can inhibit 90% ~ 100% strain growth, slightly higher than its MIC metronidazole. Concentration in 8μg/ml make 76% ~ 91% inhibition of anaerobic bacteria.
(C) The Immunosuppressive Effects:
Aloe-emodin organisms can inhibit the antibody production and suppress the capacity of carbon clearance, reducing the weight of immune organs and reduce the number of leukocytes and reduce macrophage function. 100μg/ml concentration in vitro [3H]-TDR and the [3H] Urd incorporation inhibited lymphocytes.
(D) Diarrhea Effects:
Aloe-emodin has a strong purgative activity of intestinal bacteria metabolism Aloe-emodin, rhein, rhein anthrone, which have a stronger role in diarrhea. Used as a laxative clinically with loss of appetite and enhance the role of the large intestine laxative. According to medical reports, is Aloin hyperparasite role in the human body, the hydrolysis for aloe-emodin, aloe-emodin that stimulate bowel motility, at the same time as a result of changes in osmotic pressure will help rule out intestinal waste, thereby irritant laxative to achieve this stimulating effect of diarrhea and constipation, hemorrhoids and has special curative effects. Especially in the age-related constipation, the treatment effect more obvious.
Pharmacokinetics:

 4.5mg/kg dose according to the male and female rats administered 14C-aloe emodin, given doses of 20% ~ 30% secreted into the urine, and the remaining residue in the feces. The total radioactivity in plasma 10% of the prototype drug. After administration of 1.5 to 3 hours maximum plasma concentration, when the male equivalent of aloe-emodin rats 248μg/ml, rather Aloe rhubarb female rats 441μg/ml, a high ratio of ovarian 3-fold, 10 times higher than the testis. Liver, kidney and intestinal Aloe-emodin in the high than in plasma. Aloe-emodin in the blood of the half-life of 50 hours.
To healthy volunteers for clinical trial using doses of aloe-emodin, the first blood 90 hours after administration, preparation of serum, there is no detection of aloe-emodin, rhein can be detected, 3 ~ 5 hours and 10 ~ 11 peak hours there, which is equivalent to the total of free rhein 150 ~ 160μg/ml. Emergence of two peaks of the reason may be that the drugs were part of a direct absorption of rhein, rhein from another part of aloe-emodin. Aloe-emodin by intestinal bacteria into rhein.